Unraveling a Rare Genetic Mystery: Danon Disease Clinical Case by Prof. Saule Urazalina

At the International Conference on Cardiology and Cardiovascular Science (CVS 2026), we are honored to feature Prof. Saule Urazalina from Kazakh National Medical University named after S.D. Asfendiarov, Kazakhstan, who will deliver a virtual oral presentation on a fascinating and rare medical case — Danon Disease (Clinical Case).

This unique session will shed light on a rare X-linked dominant genetic disorder, offering deep insights into its diagnosis, inheritance pattern, and clinical manifestations.

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🧬 Key Highlights from the Case Presentation

✅ Rare Disease Focus:
Danon disease, first described by Morris Danon in 1981, is characterized by a triad of cardiomyopathy, skeletal myopathy, and intellectual disability — caused by mutations in the LAMP2 gene.

✅ Patient Profile:

·         22-year-old male with asthenic build and mild intellectual disability.

·         Chief complaints: general weakness and palpitations.

·         Maternal history of cardiac abnormalities – mother had a pacemaker implanted at age 34.

✅ Diagnostic Findings:

·         EKG: High voltage, repolarization changes, and Wolff-Parkinson-White (WPW) syndrome.

·         Holter monitoring: 160 supraventricular tachycardia episodes and 1,119 extrasystoles.

·         Echocardiogram & MRI: Severe left ventricular hypertrophy; LV mass index – 246 g/m².

·         Lab findings: Elevated ALT (5.8×), AST (4.8×), increased CK-MB, normal troponin.

·         Genetic testing: Mutation c.928G>A in exon 7 of the LAMP2 gene, confirming X-linked inheritance.

·         Retinal & Muscular signs: Retinal pigment changes and skeletal myopathy.

✅ Conclusion:
The combination of hypertrophic cardiomyopathy, skeletal and retinal involvement, and LAMP2 protein deficiency confirms a clinical diagnosis of Danon Disease.

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👩‍⚕️ About the Expert Speaker

Prof. Saule Urazalina, PhD is a renowned cardiologist specializing in functional cardiac diagnostics such as EKG, echocardiography, and Holter monitoring.

·         Alumna of First Moscow Medical University (I.M. Sechenov).

·         Conducted doctoral research on subclinical atherosclerosis.

·         Completed advanced training in modern echocardiography at Tel-Aviv Sourasky Medical Center, affiliated with Tel-Aviv University.

·         Presently, she serves as Professor of Cardiology at the Kazakh National Medical University.

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🌍 Event Details

Event Name: International Conference on Cardiology and Cardiovascular Science

📅 Dates: March 26–28, 2026
📍 Venue: Singapore & Online (Hybrid)
🌐 Website: https://cardiology.miconferences.com/
📝 Abstract Submission: Submit Here
💳 Registration: Register Now

📧 Email: cardiology@mathewsconference.com
📞 Phone: +1 (312) 462-4448
💬 WhatsApp: +1 (424) 377 0967
🐦 Follow Us: X - @CardioEvent_CVS

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🚀 Join the Global Cardiology Community

This session is a must-attend for cardiologists, geneticists, and researchers interested in rare heart diseases and genetic cardiomyopathies. Gain new insights, share ideas, and network with global experts advancing cardiovascular science.

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#DanonDisease #CardiologyConference #CVS2026 #CardiacGenetics #HeartResearch #CardiovascularScience #SauleUrazalina #KazakhMedicalUniversity #CardiologyEvent #MedicalConference2026 #LAMP2Mutation #HypertrophicCardiomyopathy #GeneticDisorders #SingaporeConference #VirtualMedicalEvent

Groundbreaking Cardiac Discovery: Yasser’s Fibrillation and Bilobed Floating Heart Syndrome

A remarkable medical discovery by Dr. Yasser Mohammed Hassanain Elsayed from the Egyptian Ministry of Health is set to redefine the way cardiologists understand atrial fibrillation and cardiac anatomy. Presented at the upcoming International Conference on Cardiology and Cardiovascular Science (CVS 2026), his case report introduces new cardiovascular and radiological phenomena that mark a turning point in cardiac research.

💡 A New Perspective in Cardiology

Dr. Elsayed’s presentation, titled “Yasser’s Electrocardiographic Palpitations Wave with Bilobed Apical Floating Heart Syndrome in Yasser’s Fibrillation,” explores a rare and complex case of a young Egyptian patient suffering from chest pain and abnormal cardiac rhythms.

🔍 Key Research Insights

·         Yasser’s Fibrillation (Sinusoidal AF): A newly identified form of atrial fibrillation that balances between normal sinus rhythm and arrhythmia.

·         Bilobed Apical Floating Heart Syndrome: A never-before-documented congenital heart condition characterized by a dual-lobed apex and a floating heart appearance.

·         Yasser’s Electrocardiographic Palpitations Wave: A distinctive upright superficial ECG wave associated with unusual palpitations — another signature discovery.

·         Treatment and Response: The patient demonstrated an exceptional recovery following IV amiodarone treatment, highlighting the drug’s potential effectiveness in similar rare cardiac conditions.

·         Innovative Constellations: The combination of Yasser’s Fibrillation, Electrocardiographic Palpitations Wave, and Floating Heart Syndrome represents a new chapter in cardiovascular innovation.

👨‍⚕️ About Dr. Yasser Mohammed Hassanain Elsayed

Dr. Yasser Elsayed is a renowned cardiologist, critical care physician, and medical innovator from Egypt. With 153 published articles and 22 original scientific innovations, he has introduced multiple recognized medical concepts including Yasser’s Sign, Phenomenon, Syndrome, Procedure, and Fibrillation.
He has served as an editor for over 275 journals, reviewed 300+ scientific papers, and participated in 34 international conferences as a speaker. His contributions to medicine have earned him 177+ awards and nominations, including recognition for the Breakthrough Prize and Einstein Prize.

🌍 Event Details

Event Name: International Conference on Cardiology and Cardiovascular Science

📅 Dates: March 26–28, 2026
📍 Venue: Singapore & Online
🌐 Event Website: https://cardiology.miconferences.com/

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🔖 #CVS2026 #CardiologyConference #HeartResearch #YassersFibrillation #FloatingHeartSyndrome #CardiacInnovation #Electrocardiography #MedicalDiscovery #CardioScience2026 #MathewsConference #GlobalCardiology

Building Intelligent and Ethical Health Ecosystems: Insights from Prof. Bernd Blobel

As healthcare transitions into the era of personalized, predictive, preventive, participative precision medicine (5PM), the need for intelligent and ethical integration across systems has never been greater.

At the International Conference on Cardiology and Cardiovascular Science (CVS 2026), Prof. Dr. Bernd Blobel from the University of Regensburg, Germany, will deliver a thought-provoking keynote on principles and standards for integrating and managing future-ready health ecosystems.

Title : Principles and standards for designing and managing integration and interoperability of intelligent and ethical transformed health ecosystems

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🌍 Transforming Healthcare Through Interoperability and Ethics

In a world where digital transformation defines healthcare, Prof. Blobel emphasizes that technology alone cannot ensure success. The collaboration between humans, machines, and ethical frameworks is essential to build sustainable health systems. His keynote explores how AI, nanotechnology, edge computing, and advanced informatics can reshape healthcare while maintaining trust, transparency, and ethics.

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🔍 Key Takeaways from the Keynote

·         💡 Future of Medicine: Moving towards data-driven, patient-centered 5PM healthcare ecosystems.

·         🔬 Cross-Domain Collaboration: Integrating medical, ethical, legal, and technological frameworks to achieve true interoperability.

·         🧩 Standards and Architecture: Insights into the ISO 23903 Interoperability and Integration Reference Architecture developed by Dr. Blobel.

·         ⚙️ Top-Level Ontologies: Application of ISO/IEC 21838 for consistent modeling and formalization of health ecosystems.

·         🤖 AI and Ethics: Balancing smart technologies with moral responsibility and humanistic principles.

·         🌐 Global Implementation: Real-world examples of how standardized models are improving healthcare systems internationally.

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👨‍⚕️ About the Speaker

Prof. Dr. Bernd Blobel is a world leader in medical informatics, system integration, and digital health innovation.
He has guided major eHealth transformation projects across Europe and beyond and played a central role in developing international health IT standards through ISO, HL7, and IEEE.
As the former Head of the German National eHealth Competence Center at the University of Regensburg, his work continues to shape the future of ethical and intelligent digital healthcare.

🔗 Explore Publications

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🩺 Event Information

Event Name: International Conference on Cardiology and Cardiovascular Science

📅 Dates: March 26–28, 2026
📍 Venue: Singapore & Online (Hybrid Event)
🔗 Event Website: https://cardiology.miconferences.com/
📧 Email: cardiology@mathewsconference.com
📞 Phone: +1 (312) 462-4448
💬 WhatsApp: +1 (424) 377 0967

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🔖 Register Now

Join CVS 2026 to explore the latest innovations in cardiology, medical AI, and ethical healthcare transformation.
👉 Register Here

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#CVS2026 #CardiologyConference #HealthInnovation #PrecisionMedicine #HealthcareEthics #AIinHealthcare #Interoperability #DigitalHealth #MedicalTechnology #BerndBlobel #SmartHealthcare #ISOStandards #eHealthTransformation #GlobalCardiology

Advancing Coronary Revascularization: Huanting Liu’s Hybrid RFR-FFR Strategy Revolutionizes Decision-Making in NSTE-ACS

Presenter: Huanting Liu, Guangdong Medical University, China

Presentation Type: Poster Presentation (Virtual)

Title: Hybrid RFR-FFR decision-making strategy for physiology-guided coronary revascularization in patients with non-ST elevation acute coronary syndrome
Conference: International Conference on Cardiology and Cardiovascular Science
📅 March 26–28, 2026 | 📍 Singapore & Online
🔗 Official Website

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🌟 Research Overview

In an era where precision in cardiac care is paramount, Huanting Liu presents a groundbreaking hybrid RFR-FFR decision-making approach designed for physiology-guided coronary revascularization in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).
This innovative study bridges the gap between diagnostic efficiency and patient safety by optimizing invasive coronary assessment methods.

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🩺 Key Study Insights

·         Comprehensive Clinical Evaluation: Conducted on 253 patients (320 diseased vessels) at Cangzhou Central Hospital of Hebei Medical University between 2021–2023.

·         Hybrid Approach: Developed an RFR-FFR method to identify “gray zones” where adenosine use is selectively needed.

·         Efficiency Boost: Achieved 56.56% reduction in adenosine use without compromising diagnostic accuracy.

·         High Concordance Rate: Maintained 95.31% agreement with the FFR-only model, ensuring reliability.

·         Strong Predictive Values: Recorded 96.28% positive and 93.33% negative predictive values.

·         Clinical Advantage: Offers a safer, faster, and more cost-effective solution for coronary lesion evaluation.

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👩‍🔬 About the Researcher

Huanting Liu is a master’s student from Guangdong Medical University specializing in epidemiology and health statistics. Her research emphasizes data analytics and epidemiological methodologies, focusing on cardiovascular chronic diseases and evidence-based health solutions.

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🌍 Join the Global Discussion

Be part of the International Conference on Cardiology and Cardiovascular Science (CVS 2026) — a premier gathering for global cardiology experts, researchers, and innovators.

📧 Email: cardiology@mathewsconference.com
📞 Phone: +1 (312) 462-4448 | WhatsApp: +1 (424) 377 0967
🧾 Submit Abstract | Register Here

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#Cardiology2026 #HeartResearch #CardiovascularScience #NSTEACS #FFR #RFR #HybridApproach #CoronaryRevascularization #CardiacInnovation #CardiologyConference #MedicalResearch #SingaporeEvents