When Social Conditions Shape Children’s Hearts: New Evidence from Afghanistan

At the International Conference on Cardiology and Cardiovascular Science 2026, a compelling oral presentation by Dr. Abdul Wahed Sidiqi of Kabul University of Medical Sciences brings forward rare and valuable data on congenital heart disease (CHD) from Afghanistan—a region where evidence has been historically limited.

This hospital-based study from Kabul demonstrates that childhood heart disease is not driven by biology alone, but is deeply influenced by socioeconomic status, parental health, and maternal nutrition.

Title : Socioeconomic, parental, and nutritional factorsassociated with congenital heart disease in children: Insights from ahospital-based case-control study in Kabul, Afghanistan

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🔑 Key Insights from the Study (In Points)

📊 Study Framework

• Hospital-based case–control design

• Conducted at Ariana Medical Complex, Kabul

• Study duration: February–August 2025

• Participants:

  • 203 children diagnosed with CHD

  • 211 children without CHD

• Data captured using a 109-item structured questionnaire

• Statistical rigor ensured through odds ratios (ORs) and 95% confidence intervals

🏠 Socioeconomic Determinants

• Parental education emerged as a decisive factor:

  • Children of illiterate parents faced significantly higher CHD risk

• Household income showed a strong inverse relationship with CHD:

  • Lowest-income families experienced the highest burden

• Extended family living arrangements were associated with increased risk, highlighting household-level influences

👨‍👩‍👧 Parental Health & Lifestyle Factors

• Elevated CHD risk linked to:

  • Maternal hypertension prior to conception

  • Underweight paternal status

  • Fathers being unemployed or self-employed before conception

• Reinforces the importance of both maternal and paternal health before pregnancy

🥦 Nutritional Findings During Pregnancy

• Poor maternal nutrition significantly increased CHD risk

• Protective dietary practices included:

  • Folic acid supplementation

  • Calcium and vitamin D intake

  • Higher consumption of fruits and vegetables

• Highlights nutrition as a modifiable and cost-effective preventive strategy

🌍 Broader Public Health Significance

• CHD in Afghan children is strongly associated with preventable and modifiable factors

• Findings support:

  • Strengthening antenatal and preconception care

  • Integrating nutrition programs into maternal health services

  • Aligning healthcare, education, and social welfare policies

• Emphasizes prevention as a realistic solution in resource-limited settings

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👨‍⚕️ About the Presenter

Dr. Abdul Wahed Sidiqi is a pioneering cardiologist in Afghanistan and founder of Ariana Hospital and Ariana Medical Complex. A Fellow of the European Society of Cardiology, he has introduced echocardiography training, BLS, and ACLS programs nationwide and has received international recognition, including the Best Oral Presentation Award (Cardio Hub 2025).

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📅 Conference Snapshot

• Event: International Conference on Cardiology and Cardiovascular Science

• Dates: March 26–28, 2026

• Format: Hybrid (In-Person & Online)

• Venue: Singapore

🔗 Website: https://cardiology.miconferences.com/
📝 Abstract Submission: https://cardiology.miconferences.com/abstract-submission
🎟️ Registration: https://cardiology.miconferences.com/register

#CongenitalHeartDisease #PediatricCardiology #MaternalNutrition #ChildHealth #GlobalHeartHealth
#CardiologyResearch #CardiologyConference #PublicHealthEvidence #HealthcareEquity #CardioScience2026

TG/G Index and Gut Microbiome Patterns: New Insights from Prof. Gulshara Abildinova

Understanding how metabolic markers interact with gut microbiota is becoming increasingly vital in predicting cardiovascular disease risk. At the upcoming International Conference on Cardiology and Cardiovascular Science (March 26–28, 2026), Prof. Gulshara Abildinova from Kazakhstan will present an in-depth study exploring the relationship between the Triglyceride-Glucose (TG/G) index and the species composition of the gut microbiome in patients with insulin resistance.

Her research highlights important microbial and clinical signatures that may influence cardiovascular outcomes and metabolic health.

Title: Study of the relationship between theTriglyceride-Glucose (TG/G) index and the species ratio of the microbiome

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Study Highlights

• 189 Patients Investigated
  Participants (mean age ~49 years) included men and women diagnosed with insulin resistance, allowing a diverse metabolic profile.

• Advanced DNA Sequencing Applied
  Gut microbiome composition was analyzed using the Ion Gene Studio S5 Plus semiconductor sequencer, targeting 16S rRNA gene segments.

• Significant Clinical Correlations Found
  Elevated TG/G index values (>1.7 mmol/L) were linked to higher ESR, hemoglobin, leukocyte counts, platelets, and LDL cholesterol (p < 0.001).

• Cardiac Structure & Function Affected
  • Heart failure observed in 16% of cases
  • Diastolic dysfunction identified in 91 patients
  • Carotid intima-media thickening and plaques strongly associated with TG/G levels

• Distinctive Microbial Patterns Identified
  High TG/G values correlated with greater abundance of:
  – Bacteroidaceae
  – Prevotella copri
  – Enterobacter asburiae
  – Firmicutes and Proteobacteria

• Pro-Inflammatory Microbial Shifts Noted
  Increased Proteobacteria suggests a link between microbial imbalance, insulin resistance, and inflammation-driven cardiovascular complications.

• Holistic Assessment Recommended
  The study supports integrating microbiome analysis with cardiometabolic markers to improve early detection and risk prediction.

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About Prof. Gulshara Abildinova

Prof. Abildinova is a highly respected geneticist and professor with:

• 36 years of academic and scientific experience

• Over 200 published research papers and 65 post-doctoral publications

• 7 patents, 5 methodological guidelines, and 4 monographs

• Leadership as head of the Personalized Genomic Diagnostics Laboratory at the Presidential Administration Hospital of Kazakhstan

• Major contributions to national programs for prenatal and newborn genetic screening

Her work has played a pivotal role in advancing medical genetics and public health initiatives across Kazakhstan.

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Conference Information

Event: International Conference on Cardiology and Cardiovascular Science
Dates: March 26–28, 2026
Format: Hybrid (Singapore + Online)
Email: cardiology@mathewsconference.com
Phone: +1 (312) 462-4448
WhatsApp: +1 (424) 377 0967

🔗 Event Website: https://cardiology.miconferences.com/
🔗 Abstract Submission: https://cardiology.miconferences.com/abstract-submission
🔗 Registration: https://cardiology.miconferences.com/register
🔗 Follow on X: https://x.com/CardioEvent_CVS

#Cardiology2026 #TGIndex #GutMicrobiome #CardioMetabolicHealth #CVDResearch #InsulinResistance #MicrobiomeScience #CardiologyConference #GenomicDiagnostics #HeartHealth2026 #SingaporeConference #MedicalGenetics

Strengthening ABG Accuracy in Cardiac Care: Keynote by Prof. (Dr.) Pradeep Kumar Dabla

The International Conference on Cardiology and Cardiovascular Science, scheduled for March 26–28, 2026 as a hybrid event in Singapore and Online, will feature an insightful virtual keynote by Prof. (Dr.) Pradeep Kumar Dabla. His talk focuses on elevating the reliability of arterial blood gas (ABG) testing, especially in the high-risk domain of cardiac failure where every therapeutic decision depends on precise data.

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🔬 Why ABG Accuracy Matters in Cardiac Failure

For patients struggling with cardiac failure, ABG results guide vital interventions—oxygen therapy, ventilation strategies, and fluid management. Yet, these results are highly susceptible to preanalytical errors, often leading to misinterpretation and inappropriate clinical action.

Prof. Dabla’s keynote sheds light on how strengthening preanalytical processes and aligning with ISO 15189:2022 point-of-care testing (POCT) requirements can dramatically improve patient safety.

🩺 Keynote Title

Safeguarding Accuracy in ABG Testing: Managing Preanalytical Errors and Meeting POCT Standards Under ISO 15189:2022

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📌 Presentation Highlights: Key Takeaways

·         Identification of high-risk preanalytical errors such as sample mislabeling, heparin-induced dilution, air entrapment, delayed processing, and improper mixing.

·         Emphasis on establishing standardized sampling techniques, including balanced heparin use and proper needle-to-syringe handling.

·         Review of ISO 15189:2022 requirements for POCT, including competency-based training, documentation protocols, and personnel traceability.

·         Discussion on the role of external quality assessment programs for achieving lab-equivalent quality at the bedside.

·         Evidence showing how structured protocols significantly reduce variability and strengthen diagnostic accuracy in emergency cardiac care.

·         Case-based illustration revealing how contaminated sampling led to incorrect ABG interpretation in an acute cardiac failure patient.

·         Conclusion that vigilant preanalytical control + ISO-driven quality systems create safer pathways for clinical decision-making.

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👨‍⚕️ About Prof. (Dr.) Pradeep Kumar Dabla

Prof. Dabla is a seasoned healthcare leader with 25+ years in laboratory medicine, research, and diagnostics. His distinguished career includes:

·         Chairperson & Senior Laboratory Physician specializing in Molecular Biology, Medical Devices, AI in Diagnostics, and Laboratory Quality

·         Lead & Technical Assessor for ISO 15189:2022 and ISO 17043:2023 with NABL, Govt. of India

·         Recipient of multiple national & international awards for research on CAD risk, gene polymorphism, and diabetes-related cardiovascular disease

·         Honored with the Eminent Teacher Award and prestigious fellowships including ACBI, IMSA, MAMS, and Honorary GAPIO Fellowship 2024

·         Author of 105+ research publications, 5 book chapters, 2 books, 2 AI patents, and over 60 invited abstracts

·         A respected keynote speaker globally for advancing laboratory quality and clinical diagnostics

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📅 Event Information

Event: International Conference on Cardiology and Cardiovascular Science
Dates: March 26–28, 2026
Format: Hybrid (Singapore + Online)
Website: https://cardiology.miconferences.com/
Email: cardiology@mathewsconference.com
Phone: +1 (312) 462-4448
WhatsApp: +1 (424) 377 0967
Abstract Submission: https://cardiology.miconferences.com/abstract-submission
Registration: https://cardiology.miconferences.com/register
X Account: https://x.com/CardioEvent_CVS

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#CardioScience2026 #ABGAccuracy #ISO15189 #POCTStandards #CardiacFailureCare #DiagnosticQuality #ClinicalLaboratoryMedicine #PatientSafetyFirst #CardiologyConference #HealthcareQuality #SingaporeEvents #MedicalDiagnostics

Exploring ACE Gene Polymorphism in Chronic Heart Failure: A Study from Uzbekistan

Chronic heart failure (CHF) remains one of the most significant global health challenges, and understanding its genetic contributors is essential for better diagnosis and prevention. At the International Conference on Cardiology and Cardiovascular Science (March 26–28, 2026 | Singapore & Online), Dilnoza Tagaeva from Uzbekistan presents insightful findings on the ACE gene I/D polymorphism and its potential association with CHF in the Uzbek population.

Title: To evaluate the role of I/D polymorphism of the angiotensin-converting enzyme (ACE) gene in patients

🔬 Study Aim

The research evaluates whether the I/D polymorphism of the angiotensin-converting enzyme (ACE) gene contributes to the development of chronic heart failure among Uzbek individuals.

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📊 Key Research Highlights

1️⃣ Elevated D Allele Frequency in CHF Patients

·         D allele frequency: 51.4% in CHF patients

·         Control group: 40.25%

·         I allele was lower in CHF (48.6%) compared to controls (59.8%)

·         Despite the differences, results were not statistically significant (p = 0.4)

2️⃣ Reduced Frequency of I/I Genotype in CHF Group

·         I/I genotype: 31% in CHF patients

·         Control group: 47.1%

·         Odds ratio suggests no major increased risk of CHF for carriers of I/I

3️⃣ I/D Genotype Shows Protective Tendencies

·         I/D genotype: 35.2% (patients) vs 25.5% (controls)

·         Indicates a potential protective effect, though close to significance

·         (OR = 1.6; p = 0.6)

4️⃣ D/D Genotype May Signal Higher CHF Risk

·         D/D genotype frequency: 33.8% in CHF patients

·         This unfavorable genotype is increasingly recognized as a possible risk marker

·         Supports its role in CHF susceptibility

5️⃣ Overall Conclusion

The findings highlight the D/D genotype of the ACE gene as a potential independent marker for chronic heart failure, offering insights into genetic predisposition within the Uzbek population.

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👩‍⚕️ About Dilnoza Tagaeva

Dilnoza Tagaeva is a cardiac rehabilitation specialist dedicated to advancing cardiovascular health. Her background includes:

·         Acting Head of the Rehabilitation Laboratory at the Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation, Tashkent

·         Participation in four national research projects

·         Multiple published studies on cardiac diseases and rehabilitation therapies

Her work bridges the gap between clinical care and genetic research, offering valuable contributions to cardiovascular medicine.

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📢 International Conference on Cardiology & Cardiovascular Science – Event Details

·         Dates: March 26–28, 2026

·         Format: Hybrid (Singapore + Online)

·         Website: https://cardiology.miconferences.com/

·         Email: cardiology@mathewsconference.com

·         Phone: +1 (312) 462-4448

·         WhatsApp: +1 (424) 377 0967

·         Submit Abstract: https://cardiology.miconferences.com/abstract-submission

·         Register: https://cardiology.miconferences.com/register

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#Cardiology2026 #ACEGene #HeartFailureResearch #CardiovascularGenetics
#CVS2026 #ChronicHeartFailure #MedicalGenomics #CardiologyConference
#GeneticMarkers #HeartHealthUzbekistan #RehabilitationScience #CardiacResearch

Unraveling a Rare Genetic Mystery: Danon Disease Clinical Case by Prof. Saule Urazalina

At the International Conference on Cardiology and Cardiovascular Science (CVS 2026), we are honored to feature Prof. Saule Urazalina from Kazakh National Medical University named after S.D. Asfendiarov, Kazakhstan, who will deliver a virtual oral presentation on a fascinating and rare medical case — Danon Disease (Clinical Case).

This unique session will shed light on a rare X-linked dominant genetic disorder, offering deep insights into its diagnosis, inheritance pattern, and clinical manifestations.

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🧬 Key Highlights from the Case Presentation

✅ Rare Disease Focus:
Danon disease, first described by Morris Danon in 1981, is characterized by a triad of cardiomyopathy, skeletal myopathy, and intellectual disability — caused by mutations in the LAMP2 gene.

✅ Patient Profile:

·         22-year-old male with asthenic build and mild intellectual disability.

·         Chief complaints: general weakness and palpitations.

·         Maternal history of cardiac abnormalities – mother had a pacemaker implanted at age 34.

✅ Diagnostic Findings:

·         EKG: High voltage, repolarization changes, and Wolff-Parkinson-White (WPW) syndrome.

·         Holter monitoring: 160 supraventricular tachycardia episodes and 1,119 extrasystoles.

·         Echocardiogram & MRI: Severe left ventricular hypertrophy; LV mass index – 246 g/m².

·         Lab findings: Elevated ALT (5.8×), AST (4.8×), increased CK-MB, normal troponin.

·         Genetic testing: Mutation c.928G>A in exon 7 of the LAMP2 gene, confirming X-linked inheritance.

·         Retinal & Muscular signs: Retinal pigment changes and skeletal myopathy.

✅ Conclusion:
The combination of hypertrophic cardiomyopathy, skeletal and retinal involvement, and LAMP2 protein deficiency confirms a clinical diagnosis of Danon Disease.

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👩‍⚕️ About the Expert Speaker

Prof. Saule Urazalina, PhD is a renowned cardiologist specializing in functional cardiac diagnostics such as EKG, echocardiography, and Holter monitoring.

·         Alumna of First Moscow Medical University (I.M. Sechenov).

·         Conducted doctoral research on subclinical atherosclerosis.

·         Completed advanced training in modern echocardiography at Tel-Aviv Sourasky Medical Center, affiliated with Tel-Aviv University.

·         Presently, she serves as Professor of Cardiology at the Kazakh National Medical University.

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🌍 Event Details

Event Name: International Conference on Cardiology and Cardiovascular Science

📅 Dates: March 26–28, 2026
📍 Venue: Singapore & Online (Hybrid)
🌐 Website: https://cardiology.miconferences.com/
📝 Abstract Submission: Submit Here
💳 Registration: Register Now

📧 Email: cardiology@mathewsconference.com
📞 Phone: +1 (312) 462-4448
💬 WhatsApp: +1 (424) 377 0967
🐦 Follow Us: X - @CardioEvent_CVS

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🚀 Join the Global Cardiology Community

This session is a must-attend for cardiologists, geneticists, and researchers interested in rare heart diseases and genetic cardiomyopathies. Gain new insights, share ideas, and network with global experts advancing cardiovascular science.

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#DanonDisease #CardiologyConference #CVS2026 #CardiacGenetics #HeartResearch #CardiovascularScience #SauleUrazalina #KazakhMedicalUniversity #CardiologyEvent #MedicalConference2026 #LAMP2Mutation #HypertrophicCardiomyopathy #GeneticDisorders #SingaporeConference #VirtualMedicalEvent