Monday, January 5, 2026

Decoding Early Sex Differences in Heart Development Using Single-Cell Genomics

🧬 Research Spotlight at Cardiology & Cardiovascular Science 2026

  • Researcher: Shion Nagasawa

  • Institution: Chiba University, Japan

  • Presentation Format: Poster Presentation (In-Person)

  • Scientific Event: International Conference on Cardiology and Cardiovascular Science

  • Dates: March 26–28, 2026

  • Mode: Hybrid (Singapore & Online)

🫀 Study Title

Single Cell Analysis of Endothelial Cells in Male and Female Developing Hearts

🔍 What Makes This Study Unique

  • Investigates sex-based differences in the cardiovascular system before birth

  • Challenges the belief that cardiac sex differences arise only after hormonal influence

  • Focuses on endothelial cells, key regulators of vascular structure and function

  • Applies single-cell RNA sequencing to reveal cellular and molecular diversity

🧪 Research Approach in Brief

  • Embryonic mouse hearts analyzed at E17.5 and E12.5 developmental stages

  • Cardiac endothelial cells isolated using fluorescence-activated cell sorting (FACS)

  • Male and female cells distinguished within the same dataset using cell-multiplexing oligos

  • Public datasets leveraged to validate sex-specific gene expression patterns

📊 Key Findings at a Glance

  • Identification of endothelial subtypes:

    • Arterial

    • Two capillary populations

    • Venous endothelial cells

  • Female embryos showed a higher proportion of arterial endothelial cells

  • Male endothelial cells demonstrated increased expression of cell motility–related genes

  • Female endothelial cells showed enhanced pathways related to:

    • Endothelial differentiation

    • Response to laminar fluid shear stress

  • Similar gene expression profiles observed at earlier stages, suggesting early onset of sex differences

🧠 Scientific Significance

  • Reveals that cardiac vascular sex differences are programmed during embryogenesis

  • Provides mechanistic insight into future sex-specific cardiovascular function and disease risk

  • Supports the need for sex-aware approaches in cardiovascular research

  • Strengthens the role of single-cell technologies in developmental biology

👩‍🔬 Researcher Profile

  • PhD candidate focused on heart development and cardiovascular disease mechanisms

  • Holds a Master’s degree in Pharmaceutical Sciences from the University of Shizuoka

  • Actively engaged in translational research bridging development and disease



🌐 Conference & Participation Details

🔗 Website: https://cardiology.miconferences.com/
📝 Abstract Submission: https://cardiology.miconferences.com/abstract-submission
🎟️ Registration: https://cardiology.miconferences.com/register
❌ X: https://x.com/CardioEvent_CVS

#HeartDevelopment#CardiovascularResearch#SingleCellSequencing#EndothelialBiology#SexDifferencesInHealth#DevelopmentalBiology#CardiologyConference#TranslationalScience#WomenInScience


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Decoding Early Sex Differences in Heart Development Using Single-Cell Genomics

🧬 Research Spotlight at Cardiology & Cardiovascular Science 2026 Researcher: Shion Nagasawa Institution: Chiba University , Japan Pre...