The International Conference on Cardiology and Cardiovascular Science 2026 will feature a groundbreaking in-person oral presentation by Qiong Yuan, Southwest Medical University, China. Her talk, “DICAR-JP Regulates Ribosome Migration,” introduces a novel molecular concept that reshapes our understanding of mitochondrial protein production and opens new therapeutic avenues for diabetic cardiomyopathy (DCM).
Title: DICAR-JP regulates ribosome migration, a new theory of mitochondrial protein production
🧠 Key Concepts from the Presentation
Active Functional Fragment Identified
DICAR-JP is defined as the biologically active domain of circular RNA DICAR, responsible for its cardioprotective function.A New Molecular Paradigm
The concept of ribosome migration explains how ribosomes relocate from the endoplasmic reticulum to mitochondria to support targeted protein synthesis.Control of Nascent Peptide Translation
Interaction between DICAR-JP and NACα regulates synthesis of the OGDHL nascent peptide, a key metabolic enzyme.Mitochondrial Targeting Mechanism
DICAR-JP promotes efficient translocation of newly synthesized OGDHL peptides into mitochondria.Reversal of Metabolic Remodeling
Restoring OGDHL expression corrects pathological metabolic reprogramming in diabetic cardiomyocytes.RNA Optimization Strategy
Sequence refinement led to the development of DICAR-JP45 with enhanced biological activity.Comparable to Established Therapy
DICAR-JP45 demonstrates cardioprotective efficacy similar to empagliflozin in preventing heart remodeling.Endogenous RNA Drug Library
Proposes a new class of nucleic acid–based therapeutics derived from endogenous RNA fragments.Future Therapeutic Potential
Positions ribosome migration and DICAR-JP45 as promising targets for next-generation DCM treatment.
🌍 Why This Research Matters
This presentation bridges RNA biology, mitochondrial dynamics, and cardiovascular pharmacology, offering a transformative framework for understanding metabolic heart disease. It provides a strong foundation for developing precision RNA therapies for diabetic cardiomyopathy.
📅 Event Overview
Event: International Conference on Cardiology and Cardiovascular Science
Dates: March 26–28, 2026
Format: Hybrid (Singapore & Online)
#MitochondrialResearch #CardiovascularScience #DiabeticCardiomyopathy #RNAtherapeutics #RibosomeMigration #HeartMetabolism #CardiologyConference #HybridConference2026
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