Wednesday, October 15, 2025

Exploring Real-World Challenges in Hypertension Treatment

At the upcoming International Conference on Cardiology and Cardiovascular Science 2026, Professor Terry McCormack from Hull York Medical School, United Kingdom, will deliver an eye-opening keynote on why many patients with hypertension discontinue their prescribed medications — specifically mineralocorticoid receptor antagonists (MRAs).

His presentation, titled High Rates of Mineralocorticoid Receptor Antagonist Discontinuation in Patients with Hypertension: Insights from the Enlighten Study,” explores global treatment patterns and the pressing need for improved adherence strategies.


πŸ” Key Insights from the Enlighten Study

Study Overview:
The study examined MRA discontinuation rates among patients with hypertension (HTN) across multiple countries — the United States, United Kingdom, and Spain — between 2018 and 2023.

Data Sources:
Used large, trusted databases such as TelotrΓ³n (Spain), IQVIA EMR (US), and CPRD (UK), providing a real-world perspective on medication adherence.

Study Population:
Over 15,000 patients included, ensuring strong comparative results.

Key Findings by Country:

·         πŸ‡ΊπŸ‡Έ US: 71% discontinued within 12 months; 85% within 24 months

·         πŸ‡ͺπŸ‡Έ Spain: 63% at 12 months; 77% at 24 months

·         πŸ‡¬πŸ‡§ UK: 41% at 12 months; 58% at 24 months

Critical Takeaway:
Despite proven cardiovascular benefits, most patients stopped MRAs within one to two years, revealing major challenges in medication persistence.

Clinical Relevance:
Professor McCormack highlighted that sustaining therapy is crucial for preventing heart complications and managing long-term hypertension outcomes.

Notable Observation:
Patients in the UK demonstrated better adherence than those in the US and Spain, suggesting systemic and clinical practice differences worth further exploration.


πŸ‘¨⚕️ About Professor Terry McCormack

·         General Practitioner & Honorary Professor of Primary Care Cardiovascular Medicine, Hull York Medical School

·         Immediate Past President, British and Irish Hypertension Society

·         Contributed to NICE and AAGBI/BHS clinical guidelines

·         Editor, British Journal of Cardiology

·         Fellow, European Society of Cardiology
His decades-long contribution to cardiovascular research and clinical guidelines continues to shape hypertension management worldwide.


🌍 Join the Global Cardiology Dialogue

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Event Name: International Conference on Cardiology and Cardiovascular Science

πŸ“© Email: cardiology@mathewsconference.com
πŸ“ž Phone: +1 (312) 462-4448
πŸ’¬ WhatsApp: +1 (424) 377 0967

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