💡 Presentation Overview
Title: Lysine
2-hydroxyisobutyrylation of HXK1 alters energy metabolism and KATP channel
function in the atrium from patients with atrial fibrillation
Presenter:
Dr.
Guo-Wei
He, Tianjin University, China
🎤 Session:
Oral In-Person Presentation
❤️ Understanding the Science Behind
Atrial Fibrillation
Atrial
fibrillation (AF) — the most common cardiac arrhythmia — continues to challenge
cardiovascular specialists worldwide. While many studies focus on electrical
irregularities, Dr. Guo-Wei He explored a molecular-level
mechanism: how lysine 2-hydroxyisobutyrylation (Khib) impacts energy
metabolism and ion channel activity in the human atrium.
🧠 Key Research
Highlights
·
🧩 Research
Approach:
o
Conducted PTM proteomics on atrial tissues from patients
with AF and sinus rhythm undergoing cardiac surgery.
o
Validated functional changes of key proteins at cellular and
electrophysiological levels.
·
⚙️ Major Discoveries:
o
Identified 191 modified Khib sites across several metabolic and
energy-regulating proteins.
o
Significant alterations found in glycolysis (HXK1, TPIS, PGM1),
tricarboxylic acid cycle (IDH3A, MDHC), and oxidative respiration (NDUS2,
ATPB).
o
HXK1 K418hib,
regulated by HDAC2,
reduces glucose-binding efficiency and catalytic function — leading to low ATP and
glucose-6-phosphate production.
o
Reduced energy availability triggered increased
Kir6.2 protein expression, enhanced KATP channel current,
and shortened
action potential duration (APD), contributing to arrhythmia.
·
🔍 Scientific
Conclusion:
This study establishes Khib modification of HXK1 as a novel
regulatory mechanism affecting cellular energy balance and
cardiac excitability — providing fresh insight into atrial
fibrillation pathophysiology and potential therapeutic
targets.
👨⚕️ About
the Speaker
Dr. Guo-Wei He, an eminent cardiovascular
surgeon and researcher from Tianjin University, China, has made transformative
contributions to cardiac surgery and molecular cardiology.
·
Performed over 7,000 open-heart surgeries.
·
Secured 80+ national and international research grants.
·
Developed the groundbreaking “He Classification”
and “He
Solutions” for CABG grafts.
·
Recipient of First-Class Science Awards from Tianjin
Municipality (2012) and the China Medicine Education Association (2021).
·
Authored 409 SCI(E)-indexed publications, cited 10,654+ times,
with an H-index
of 55.
·
Listed among the World’s Top 2% Scientists (1999, 2020–2022).
His
research focuses on genomics, proteomics, metabolomics, and mechanistic
studies in cardiovascular disease, integrating basic
molecular science with clinical cardiology.
🔗 Conference
Links
🧾 Submit
Abstract: https://cardiology.miconferences.com/abstract-submission
🎟️ Register
Here: https://cardiology.miconferences.com/register
⚕️ International
Conference on Cardiology and Cardiovascular Science (CVS 2026)
📅 Dates:
March 26–28, 2026
📍 Venue:
Singapore & Online (Hybrid Event)
📧 Email:
cardiology@mathewsconference.com
📞 Phone:
+1 (312) 462-4448 | 📱 WhatsApp:
+1 (424) 377 0967
🌐 Website:
https://cardiology.miconferences.com/
🐦 Follow on X:
https://x.com/CardioEvent_CVS
#CVS2026 #CardiologyConference
#CardioEvent2026 #AtrialFibrillation #HeartResearch #CardiovascularScience
#EnergyMetabolism #KhibModification #MolecularCardiology #HXK1
#Electrophysiology #Proteomics #ArrhythmiaResearch #HeartHealth
#SingaporeConference #CardiacInnovation #CardiologyUpdates
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