Chronic heart failure (CHF) remains one of the most significant global health challenges, and understanding its genetic contributors is essential for better diagnosis and prevention. At the International Conference on Cardiology and Cardiovascular Science (March 26–28, 2026 | Singapore & Online), Dilnoza Tagaeva from Uzbekistan presents insightful findings on the ACE gene I/D polymorphism and its potential association with CHF in the Uzbek population.
Title: To
evaluate the role of I/D polymorphism of the angiotensin-converting enzyme
(ACE) gene in patients
🔬 Study Aim
The
research evaluates whether the I/D polymorphism of the
angiotensin-converting enzyme (ACE) gene contributes
to the development of chronic heart failure among Uzbek individuals.
📊 Key Research Highlights
1️⃣ Elevated D Allele Frequency in CHF Patients
·
D allele frequency: 51.4% in CHF patients
·
Control group: 40.25%
·
I allele was lower in CHF (48.6%) compared to controls (59.8%)
·
Despite the differences, results were not
statistically significant (p = 0.4)
2️⃣ Reduced Frequency of I/I Genotype in CHF Group
·
I/I genotype: 31% in CHF patients
·
Control group: 47.1%
·
Odds ratio suggests no major increased risk
of CHF for carriers of I/I
3️⃣ I/D Genotype Shows Protective Tendencies
·
I/D genotype: 35.2% (patients)
vs 25.5% (controls)
·
Indicates a potential protective effect,
though close to significance
·
(OR = 1.6; p = 0.6)
4️⃣ D/D Genotype May Signal Higher CHF Risk
·
D/D genotype frequency: 33.8% in CHF
patients
·
This unfavorable genotype
is increasingly recognized as a possible risk marker
·
Supports its role in CHF susceptibility
5️⃣ Overall Conclusion
The
findings highlight the D/D genotype of the ACE gene
as a potential independent marker for chronic heart failure,
offering insights into genetic predisposition within the Uzbek population.
👩⚕️ About Dilnoza Tagaeva
Dilnoza
Tagaeva is a cardiac rehabilitation specialist
dedicated to advancing cardiovascular health. Her background includes:
·
Acting Head of the Rehabilitation Laboratory
at the Republican Specialized Scientific and Practical Medical Center for
Therapy and Medical Rehabilitation, Tashkent
·
Participation in four national research projects
·
Multiple published studies on cardiac
diseases and rehabilitation therapies
Her
work bridges the gap between clinical care and genetic research,
offering valuable contributions to cardiovascular medicine.
📢 International Conference on Cardiology & Cardiovascular Science – Event Details
·
Dates:
March 26–28, 2026
·
Format:
Hybrid (Singapore + Online)
·
Website: https://cardiology.miconferences.com/
·
Email:
cardiology@mathewsconference.com
·
Phone:
+1 (312) 462-4448
·
WhatsApp:
+1 (424) 377 0967
·
Submit Abstract: https://cardiology.miconferences.com/abstract-submission
·
Register: https://cardiology.miconferences.com/register
#Cardiology2026 #ACEGene
#HeartFailureResearch #CardiovascularGenetics
#CVS2026 #ChronicHeartFailure #MedicalGenomics #CardiologyConference
#GeneticMarkers #HeartHealthUzbekistan #RehabilitationScience #CardiacResearch
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