⚕️ Exploring the Link Between the TG/G Index and Gut Microbiome Composition
Presenter: Gulshara
President Administration Hospital, Republic of
Kazakhstan
Title: Study of the relationship between the Triglyceride-Glucose
(TG/G) index and the species ratio of the microbiome
At the upcoming Heart Conference, Prof. Gulshara
Zhusupovna will present ground breaking research examining how metabolic
markers interact with gut microbiota in patients with insulin resistance.
🔬 Research Overview
The Triglyceride-Glucose (TG/G) index has become a
practical and reliable indicator of insulin resistance. Elevated TG/G values
are strongly associated with cardiovascular complications, including vascular
calcification, carotid artery narrowing, and coronary artery disease. However,
emerging research suggests that metabolic disorders are not solely biochemical
in nature — they may also be influenced by gut microbial composition.
This study aimed to investigate whether variations
in the TG/G index correlate with specific shifts in gut microbiome species.
🧪 Study Design and Methodology
The research involved 189 patients diagnosed with
insulin resistance (average age 49.3±7.2 years; 121 women and 68 men).
Fecal samples were processed using the PureLink™
Microbiome DNA Purification Kit, and sequencing of the 16S rRNA gene was
conducted using the Ion Gene Studio S5 Plus platform. This advanced genomic
approach enabled precise identification of microbial species and phyla present
in each sample.
📊 Key Clinical Findings
The TG/G index demonstrated strong associations
with multiple laboratory and cardiovascular indicators:
• 16% of participants had heart failure
• 92% were receiving effective antihypertensive therapy
• TG/G values >1.7 mmol/L correlated with elevated ESR, hemoglobin,
leukocytes, neutrophils, lymphocytes, platelets, and LDL cholesterol
(p<0.001)
• Echocardiography revealed impaired diastolic function in 91 patients
• Carotid ultrasound showed intima-media thickening in 24 individuals
Higher TG/G levels were closely linked with
atherosclerotic plaque presence and structural cardiac changes.
🦠 Microbiome Insights
Sequencing analysis revealed that elevated TG/G
levels were associated with increased abundance of:
• Bacteroidaceae
• Prevotella copri
• Enterobacter asburiae
• Phyla Firmicutes
• Phyla Proteobacteria
Notably, enrichment of Proteobacteria — often
associated with inflammatory processes — suggests that gut microbial imbalance
may contribute to systemic inflammation, insulin resistance, and cardiovascular
disease progression.
🧠 Clinical Significance
These findings reinforce the concept that metabolic
and cardiovascular health are closely intertwined with gut microbiome
composition. The TG/G index not only serves as a metabolic marker but may also
reflect underlying inflammatory microbial shifts.
Integrating microbiome profiling alongside
conventional laboratory markers could improve risk assessment and open new
pathways for personalized prevention strategies in cardiovascular medicine.
👩⚕️ About Prof.
Gulshara Zhusupovna
Abildinova Gulshara Zhusupovna, born in 1961 in the
Republic of Kazakhstan, is a distinguished geneticist of the highest category
and Doctor of Medical Sciences. She serves as Professor and Head of the
Laboratory of Personalized Genomic Diagnostics at the Hospital of the
Presidential Administration of the Republic of Kazakhstan.
With 36 years of scientific and academic
experience, she has authored 200 scientific publications, including 65
international papers following her doctoral dissertation, 7 patents, 5 methodological
recommendations, and 4 monographs.
🌍 Join the Conference
Be part of the evolving science redefining cardiogenic shock management.
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